What Are the Early Symptoms of Hormone Receptor–Positive Breast Cancer?

Hormone receptor–positive breast cancer, which includes estrogen receptor–positive (ER+) and progesterone receptor–positive (PR+) types, is the most common form of breast cancer in the United States. These cancers grow in response to hormones like estrogen and progesterone. Detecting early signs can make a major difference in treatment outcomes.

Possible Early Symptoms

Although early hormone receptor–positive breast cancer may not cause noticeable symptoms, some early warning signs include:

  • Breast lump – A firm lump in the breast or underarm area.
  • Changes in breast size or shape – One breast appears larger or shaped differently.
  • Skin changes – Redness, dimpling, or thickening of the breast skin.
  • Nipple changes – Inversion (turning inward), new positioning, or unusual discharge, especially if bloody.
  • Persistent breast pain – Ongoing localized pain not linked to the menstrual cycle.

Why Early Detection Matters

Hormone receptor–positive breast cancers often grow more slowly than other types, but they can still spread. When detected early:

  • Survival rates are much higher.
  • Hormone therapy can effectively block hormones that fuel cancer growth.
  • Treatment options may be less aggressive.

What You Can Do

  • Get regular screenings: Mammograms are recommended starting at age 40, or earlier for those at higher risk.
  • Be aware of breast changes: Report any unusual symptoms to a doctor promptly.
  • Know your risk factors: Family history, obesity, and hormone replacement therapy can increase risk.

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